Solutions of DNA-based molecules can be taught to play a simple game in a process that does not require the operator to be familiar with the underlying molecular programming.
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Privman, V. Learning through play. Nature Nanotech 5, 767–768 (2010). https://doi.org/10.1038/nnano.2010.221
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DOI: https://doi.org/10.1038/nnano.2010.221