Large cargos stop protein filaments from rotating as they glide along a surface coated with motor proteins, but small cargos do not.
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Oiwa, K., Kojima, H. Keep on moving. Nature Nanotech 3, 531–532 (2008). https://doi.org/10.1038/nnano.2008.248
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DOI: https://doi.org/10.1038/nnano.2008.248