We present a synthetic molecular motor capable of autonomous nanoscale transport in solution. Inspired by bacterial pathogens such as Rickettsia rickettsii, which locomote by inducing the polymerization of the protein actin at their surfaces to form ‘comet tails’1, the motor operates by polymerizing a double-helical DNA tail2. DNA strands are propelled processively at the living end of the growing polymers, demonstrating autonomous locomotion powered by the free energy of DNA hybridization.
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We thank J. S. Bois for helpful discussions, J. Padilla for performing the early sequence design calculations, J. N. Zadeh for the use of unpublished multi-objective sequence design software, J. M. Schaeffer for the use of unpublished multi-stranded kinetics simulation software and R. Barish and R. Hariadi for guidance on the use of DNA origamis for patterning polymerization reactions. This work was funded by NSF-CCF-CAREER-0448835, NSF-CHE-0533064 (Center for Molecular Cybernetics), NSF-CCF-0622254, NSF-DMS-0506468.
The authors declare no competing financial interests.
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Venkataraman, S., Dirks, R., Rothemund, P. et al. An autonomous polymerization motor powered by DNA hybridization. Nature Nanotech 2, 490–494 (2007). https://doi.org/10.1038/nnano.2007.225
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