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Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

Nature Neuroscience volume 5, pages 299300 (2002) | Download Citation

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Abstract

Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb1 in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activating ATP-sensitive K+ channels (KATP channels)2. Here we show that leptin inhibits hippocampal neurons via phosphoinositide 3-kinase (PI3-kinase)–driven activation of large conductance, calcium-activated K+ channels (BK channels), but not KATP channels. This may be an important mechanism for regulating hippocampal excitability.

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References

  1. 1.

    et al. Cell 83, 1263–1271 (1995).

  2. 2.

    , , , & Nature 390, 521–525 (1997).

  3. 3.

    , , , & J. Physiol. 504, 527–535 (1997).

  4. 4.

    Biochim. Biophys. Acta 943, 419–427 (1988).

  5. 5.

    & Eur. J. Neurosci. 6, 607–617 (1994).

  6. 6.

    , , & News Physiol. Sci. 13, 112–117 (1998).

  7. 7.

    Acta. Physiol. Scand. Suppl. 582, 13 (1989).

  8. 8.

    et al. J. Biol. Chem. 275, 4660–4669 (2000).

  9. 9.

    , & J. Neurosci. 21, RC186 (1–6) (2001).

  10. 10.

    et al. Nature 411, 480–484 (2001).

  11. 11.

    , & Am. J. Physiol. 274, R1468–R1472 (1998).

  12. 12.

    et al. FEBS Lett. 474, 99–106 (2000).

  13. 13.

    , & Proc. Natl. Acad. Sci. 97, 5562–5567 (2000).

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Acknowledgements

This work is supported by The Wellcome Trust (grant nos. 055291 & 042726). J.H. is a Wellcome RCD Fellow.

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Affiliations

  1. Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK

    • Lynne J. Shanley
    • , Andrew J. Irving
    • , Mark G. Rae
    • , Mike L.J. Ashford
    •  & Jenni Harvey

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jenni Harvey.

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DOI

https://doi.org/10.1038/nn824

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