Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
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We would like to thank Q. Ha, M. Ha and J. Yu for superb technical assistance and J. Lu, N.L. Chamberlin, J.K. Elmquist and O. Hayaishi for critical reading of the manuscript and valuable comments. This research was supported by US Public Health Service grants NS33987 and HL60292.
The authors declare no competing financial interests.
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Lazarus, M., Yoshida, K., Coppari, R. et al. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 10, 1131–1133 (2007). https://doi.org/10.1038/nn1949
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