Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cortical feed-forward networks for binding different streams of sensory information

Abstract

Different streams of sensory information are transmitted to the cortex where they are merged into a percept in a process often termed 'binding.' Using recordings from triplets of rat cortical layer 2/3 and layer 5 pyramidal neurons, we show that specific subnetworks within layer 5 receive input from different layer 2/3 subnetworks. This cortical microarchitecture may represent a mechanism that enables the main output of the cortex (layer 5) to bind different features of a sensory stimulus.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: L2/3 neurons target the same L5 subnetwork.
Figure 2: L5 neurons integrate inputs from different L2/3 subnetworks.

References

  1. 1

    Hubel, D.H. & Wiesel, T.N. J. Physiol. (Lond.) 160, 106–154 (1962).

    CAS  Article  Google Scholar 

  2. 2

    Mountcastle, V.B. J. Neurophysiol. 20, 408–434 (1957).

    CAS  Article  Google Scholar 

  3. 3

    Song, S., Sjostrom, P.J., Reigl, M., Nelson, S. & Chklovskii, D.B. PLoS Biol. [online] 3, e68 (2005) (doi:10.1371/journal.pbio.0030068).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4

    Wang, Y. et al. Nat. Neurosci. 9, 534–542 (2006).

    CAS  Article  Google Scholar 

  5. 5

    Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. Nature 433, 868–873 (2005).

    CAS  Article  Google Scholar 

  6. 6

    Shepherd, G.M. & Svoboda, K. J. Neurosci. 25, 5670–5679 (2005).

    CAS  Article  Google Scholar 

  7. 7

    Bosking, W.H., Zhang, Y., Schofield, B. & Fitzpatrick, D. J. Neurosci. 17, 2112–2127 (1997).

    CAS  Article  Google Scholar 

  8. 8

    Marino, J. et al. Nat. Neurosci. 8, 194–201 (2005).

    CAS  Article  Google Scholar 

  9. 9

    Sincich, L.C. & Blasdel, G.G. J. Neurosci. 21, 4416–4426 (2001).

    CAS  Article  Google Scholar 

  10. 10

    Weliky, M., Kandler, K., Fitzpatrick, D. & Katz, L.C. Neuron 15, 541–552 (1995).

    CAS  Article  Google Scholar 

  11. 11

    Berman, N., Payne, B.R., Labar, D.R. & Murphy, E.H. J. Neurophysiol. 48, 1362–1377 (1982).

    CAS  Article  Google Scholar 

  12. 12

    Martinez, L.M. et al. Nat. Neurosci. 8, 372–379 (2005).

    CAS  Article  Google Scholar 

  13. 13

    Williams, S.R. & Stuart, G.J. Science 295, 1907–1910 (2002).

    CAS  Article  Google Scholar 

  14. 14

    Kampa, B.M., Letzkus, J.J. & Stuart, G.J. J. Physiol. (Lond.) 574, 283–290 (2006).

    CAS  Article  Google Scholar 

  15. 15

    Letzkus, J.J., Kampa, B.M. & Stuart, G.J. J. Neurosci. 26, 10420–10429 (2006).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank C. Stricker and J. Bekkers for help with the analysis and F. Helmchen, C. Gee and W. Schweer for comments on the manuscript.

Author information

Affiliations

Authors

Contributions

B.M.K. designed the experiments and did the calculations; B.M.K. and J.J.L. performed the experiments and data analysis; B.M.K., J.J.L. and G.J.S. jointly discussed the results and wrote the manuscript.

Corresponding author

Correspondence to Björn M Kampa.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Figure 1

Integrative feed-forward networks in the neocortex. (PDF 41 kb)

Supplementary Methods (PDF 29 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kampa, B., Letzkus, J. & Stuart, G. Cortical feed-forward networks for binding different streams of sensory information. Nat Neurosci 9, 1472–1473 (2006). https://doi.org/10.1038/nn1798

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing