Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Anterior cingulate cortex responds differentially to expectancy violation and social rejection

Abstract

This study investigated human anterior cingulate cortex (ACC) involvement during a task that dissociated expectancy violation from social rejection. Across two studies, participants underwent functional magnetic resonance imaging while making social judgments and receiving fictitious feedback that was either positive or negative and consistent or inconsistent with their expectations. The results demonstrate that the dorsal ACC is sensitive to expectancy violations, whereas the ventral ACC is differentially responsive to social feedback.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Representation of the subcomponents of a complete trial.
Figure 2: Differential ACC response to expectancy violation and social feedback.

References

  1. Eisenberger, N.I., Lieberman, M.D. & Williams, K. Science 302, 290–292 (2003).

    Article  CAS  Google Scholar 

  2. Bush, G., Luu, P. & Posner, M.I. Trends Cogn. Sci. 4, 215–222 (2000).

    Article  CAS  Google Scholar 

  3. Botvinick, M.M., Cohen, J.D. & Carter, C.S. Trends Cogn. Sci. 8, 539–546 (2004).

    Article  Google Scholar 

  4. Carter, C.S. et al. Science 280, 747–749 (1998).

    Article  CAS  Google Scholar 

  5. Whalen, P.J. et al. Biol. Psychiatry 44, 1219–1228 (1998).

    Article  CAS  Google Scholar 

  6. Condon, J.W. & Crano, W.D. J. Pers. Soc. Psychol. 54, 789–797 (1988).

    Article  Google Scholar 

  7. Newcomb, T.M. The Acquaintance Process (Holt, Reinhart and Winston, New York, 1961).

    Book  Google Scholar 

Download references

Acknowledgements

We thank E. Cross, J. Dobson, T. Johnstone, N. Magoon, T. Moran, J. Van Horn and P. Whalen. Supported by the National Institute of Mental Health (MH59282, MH66720). L.H.S. is a National Science Foundation Graduate Research Fellow.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to William M Kelley.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

The Region x Expectancy Violation and Region Feedback x Type interactions reported in Figure 1 were independently present in each study. (PDF 96 kb)

Supplementary Table 1

Identification of BOLD signal changes associated with the main effects of expectancy violation and feedback type. (PDF 86 kb)

Supplementary Methods (PDF 103 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Somerville, L., Heatherton, T. & Kelley, W. Anterior cingulate cortex responds differentially to expectancy violation and social rejection. Nat Neurosci 9, 1007–1008 (2006). https://doi.org/10.1038/nn1728

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1728

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing