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Experience-dependent modification of mechanisms of long-term depression

Nature Neuroscience volume 9, pages 170–172 (2006)Cite this article

Abstract

Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.

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Figure 1: LTD depends on the activation of mGluR5 in neonatal rats (P7–P12) but on the activation of mAChRs in adolescent rats (P28–P35).
Figure 2: The switch in LTD mechanisms is a consequence of sensory experience during development.
Figure 3: Developmental and dark rearing–induced changes in mGluR5 and mAChR M1 protein abundance in the perirhinal cortex (Pr).

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Acknowledgements

This work was supported by the Royal Society (K.C.), the Brain Research Center of the 21st Century Frontier Research Program (K.C.), the Ministry of Science and Technology, South Korea (S.B.O., grant number M103KV010009-04K2201-00930), the Medical Research Council and the Wellcome Trust (Z.I.B., E.M.). S.M.B. is a PhD student funded by the Medical Research Council.

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Author notes

  1. Zafar I Bashir and Kwangwook Cho: These authors contributed equally to this work.

Authors and Affiliations

  1. Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK

    Jihoon Jo, Heon Seok & Kwangwook Cho

  2. Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK

    Simon M Ball, Peter V Massey, Elek Molnar & Zafar I Bashir

  3. Department of Physiology, Molecular and Cellular Neuroscience Program, College of Dentistry, Seoul National University, Yeongeon-Dong Chongno-Ku, Seoul, 110-749, South Korea

    Seog Bae Oh

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  1. Jihoon Jo
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Correspondence to Kwangwook Cho.

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Supplementary information

Supplementary Figure 1

LTD due to 5Hz stimulation of the entorhinal side depends on postsynaptic calcium and PKC cascade in young PC. (PDF 66 kb)

Supplementary Methods (PDF 79 kb)

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Jo, J., Ball, S., Seok, H. et al. Experience-dependent modification of mechanisms of long-term depression. Nat Neurosci 9, 170–172 (2006). https://doi.org/10.1038/nn1637

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