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Neural correlates of binocular rivalry in the human lateral geniculate nucleus

Nature Neuroscience volume 8, pages 15951602 (2005) | Download Citation

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Abstract

When dissimilar images are presented to the two eyes, they compete for perceptual dominance so that only one image is visible at a time while the other one is suppressed. Neural correlates of such binocular rivalry have been found at multiple stages of visual processing, including striate and extrastriate visual cortex. However, little is known about the role of subcortical processing during binocular rivalry. Here we used fMRI to measure neural activity in the human LGN while subjects viewed contrast-modulated gratings presented dichoptically. Neural activity in the LGN correlated strongly with the subjects' reported percepts, such that activity increased when a high-contrast grating was perceived and decreased when a low-contrast grating was perceived. Our results provide evidence for a functional role of the LGN in binocular rivalry and suggest that the LGN, traditionally viewed as the gateway to the visual cortex, may be an early gatekeeper of visual awareness.

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Acknowledgements

We thank K. Weiner for help with manuscript preparation. This study was supported by NIH grants R01MH-64043, P50MH-62196 and T32 MH065214. K.W. was also supported by the German National Academic Foundation and the German Academic Exchange Service.

Author information

Affiliations

  1. Department of Psychology, Center for the Study of Brain, Mind, and Behavior, Princeton University, Princeton, New Jersey 08544, USA.

    • Klaus Wunderlich
    • , Keith A Schneider
    •  & Sabine Kastner

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Sabine Kastner.

Supplementary information

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  1. 1.

    Supplementary Fig. 1

    Checkerboard localizer.

  2. 2.

    Supplementary Fig. 2

    Behavioral results.

  3. 3.

    Supplementary Fig. 3

    fMRI signal amplitudes in LGN and V1 during rivalry (red) and physical alternations (black).

  4. 4.

    Supplementary Table 1

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DOI

https://doi.org/10.1038/nn1554

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