Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

Abstract

The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Orexigen-sensitive pacemaker activity in ARC NPY/AgRP neurons.
Figure 2: Mechanisms underlying leptin-induced inhibition of and orexigen-induced activation of ARC pacemaker cells.

References

  1. Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D & Ashford, M.L.J. Nature 390, 521–525 (1997).

    CAS  Article  Google Scholar 

  2. Spanswick, D., Smith, M.A., Mirshamsi, S., Routh, V.H & Ashford, M.L. Nat. Neurosci. 3, 757–758 (2000).

    CAS  Article  Google Scholar 

  3. Cowley, M.A. et al. Neuron 37, 649–661 (2003).

    CAS  Article  Google Scholar 

  4. Burdakov, D., Liss, B. & Ashcroft, F.M. J. Neurosci. 23, 4951–4957 (2003).

    CAS  Article  Google Scholar 

  5. Chronwall, B.M. Peptides 6, 1–11 (1985).

    CAS  Article  Google Scholar 

  6. Dutton, A. & Dyball, R.E. J. Physiol. 290, 433–440 (1979).

    CAS  Article  Google Scholar 

  7. Bicknell, R.J. & Leng, G. Neuroendocrinology 33, 295–299 (1981).

    CAS  Article  Google Scholar 

  8. Huguenard, J.R. Annu. Rev. Physiol. 58, 329–348 (1996).

    CAS  Article  Google Scholar 

  9. Cummings, D.E. & Schwartz, M.W. Annu. Rev. Med. 54, 453–471 (2003).

    CAS  Article  Google Scholar 

  10. Nakazato, M. et al. Nature 409, 194–198 (2001).

    CAS  Article  Google Scholar 

  11. Wang, L., Saint-Pierre, D.H. & Taché, Y. Neurosci. Lett. 325, 47–51 (2002).

    CAS  Article  Google Scholar 

  12. Dube, M.G., Horvath, T.L., Kalra, P.S & Kalra, S.P. Peptides 21, 1557–1560 (2000).

    CAS  Article  Google Scholar 

  13. Jain, M.R., Horvath, T.L., Kalra, P.S. & Kalra, S.P. Regul. Pept. 87, 19–24 (2000).

    CAS  Article  Google Scholar 

  14. Yamanaka, A. et al. Brain Res. 859, 404–409 (2000).

    CAS  Article  Google Scholar 

  15. Poulain, D.A. & Wakerley, J.B. Neuroscience 7, 773–808 (1982).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

Financial support from the Biotechnology and Biological Sciences Research Council (BBSRC), the Foundation for Prader-Willi Research and British Heart Foundation (BHF) is gratefully acknowledged.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Spanswick.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

van den Top, M., Lee, K., Whyment, A. et al. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7, 493–494 (2004). https://doi.org/10.1038/nn1226

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1226

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing