Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Hippocampal theta rhythms follow the beat of their own drum

The firing of most hippocampal neurons is modulated by the theta rhythm, but it's not clear how and where the rhythm is generated. A study now shows that the required machinery for theta generation lies in local circuits of the hippocampus.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The upper trace shows theta recorded from the CA1 apical dendrites of a freely moving rat (L.L.C. and E.I.M., unpublished data), whereas the lower trace shows theta waves in the whole-hippocampus preparation of Goutagny et al.4 (their Fig. 1c).

References

  1. Green, J.D. & Arduini, A.A. J. Neurophysiol. 17, 533–557 (1954).

    CAS  Article  Google Scholar 

  2. Petsche, H., Stumpf, C. & Gogolak, G. Electroencephalogr. Clin. Neurophysiol. 14, 202–211 (1962).

    CAS  Article  Google Scholar 

  3. Stewart, M. & Fox, S.E. Trends Neurosci. 13, 163–168 (1990).

    CAS  Article  Google Scholar 

  4. Goutagny, R., Jackson, J. & Williams, S. Nat. Neurosci. 12, 1491–1493 (2009).

    CAS  Article  Google Scholar 

  5. Konopacki, J., Bland, B.H. & Roth, S.H. Brain Res. 451, 33–42 (1988).

    CAS  Article  Google Scholar 

  6. Gillies, M.J. et al. J. Physiol. (Lond.) 543, 779–793 (2002).

    CAS  Article  Google Scholar 

  7. Williams, J.H. & Kauer, J.A. J. Neurophysiol. 78, 2631–2640 (1997).

    CAS  Article  Google Scholar 

  8. Bland, B.H. Prog. Neurobiol. 26, 1–54 (1986).

    CAS  Article  Google Scholar 

  9. Csicsvari, J., Hirase, H., Czurko, A., Mamiya, A. & Buzsaki, G. J. Neurosci. 19, 274–287 (1999).

    CAS  Article  Google Scholar 

  10. Buzsáki, G. Neuron 33, 325–340 (2002).

    Article  Google Scholar 

  11. Somogyi, P. & Klausberger, T. J. Physiol. (Lond.) 562, 9–26 (2005).

    CAS  Article  Google Scholar 

  12. Lubenov, E.V. & Siapas, A.G. Nature 459, 534–539 (2009).

    CAS  Article  Google Scholar 

  13. Kramis, R., Vanderwolf, C.H. & Bland, B.H. Exp. Neurol. 49, 58–85 (1975).

    CAS  Article  Google Scholar 

  14. Maurer, A.P., Vanrhoads, S.R., Sutherland, G.R., Lipa, P. & McNaughton, B.L. Hippocampus 15, 841–852 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edvard I Moser.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Colgin, L., Moser, E. Hippocampal theta rhythms follow the beat of their own drum. Nat Neurosci 12, 1483–1484 (2009). https://doi.org/10.1038/nn1209-1483

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1209-1483

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing