Preparatory activity in motor cortex reflects learning of local visuomotor skills

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Abstract

In humans, learning to produce correct visually guided movements to adapt to new sensorimotor conditions requires the formation of an internal model that represents the new transformation between visual input and the required motor command. When the new environment requires adaptation to directional errors, learning generalizes poorly to untrained locations and directions, indicating that such learning is local. Here we replicated these behavioral findings in rhesus monkeys using a visuomotor rotation task and simultaneously recorded neuronal activity. Specific changes in activity were observed only in a subpopulation of cells in the motor cortex with directional properties corresponding to the locally learned rotation. These changes adhered to the dynamics of behavior during learning and persisted between learning and relearning of the same rotation. These findings suggest a neural mechanism for the locality of newly acquired sensorimotor tasks and provide electrophysiological evidence for their retention in working memory.

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Figure 1: Experimental design and recording locations.
Figure 2: Movement kinematics during and after learning.
Figure 3: Similar behavior before and after learning.
Figure 4: Increase in preparatory activity (PA) during learning trials, but not in movement-related activity (MRA).
Figure 5: Temporal pattern of changes in neuronal and muscular activity during learning.
Figure 6: Learning-induced changes in single cells.
Figure 7: Learning-induced changes as revealed by comparing population activities before and after learning.
Figure 8: Learning-induced changes were specific and were not observed for mere repetition of movement, for non-learned directions, or for movement-related activity.

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Acknowledgements

We thank S. Wise, S. Cardoso de Oliveira and R. Shadmehr for discussions and comments on earlier versions of this manuscript, and G. Goelman for the MRI. This study was partly supported by a Center of Excellence grant (8006/00) administrated by the Israeli Science Foundation (ISF) and by the German Federal Ministry of Education and Research (BMBF) within the framework of German-Israeli project cooperation (DIP). R.P. was supported by the Constantiner fellowship.

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Correspondence to Rony Paz.

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