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Turning by asymmetric actin

Axon guidance requires local protein synthesis at the growth cone. Two new studies show that guidance cues induce asymmetric targeting and translation of β-actin (Actb) mRNA. Such asymmetry may be the mechanism that underlies growth cone turning.

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Figure 1: A model for guidance cue–induced asymmetric transport and translation of β-actin mRNA that initiates growth cone turning.

Kim Caesar


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Ming, Gl. Turning by asymmetric actin. Nat Neurosci 9, 1201–1203 (2006).

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