A study in this issue finds that under conditions of intense activity at specific inhibitory synapses, the voltage gated Cl− channel CIC-2 is vital for allowing efflux of accumulated internal Cl−.
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References
Thompson, S.M. & Gahwiler, B.H. J. Neurophysiol. 61, 501–511 (1989).
Földy, C., Lee, S.-H., Morgan, R.J. & Soltesz, I. Regulation of fast-spiking cell synapses by the chloride channel ClC-2. Nat. Neurosci. 13, 1047–1049 (2010).
Freund, T.F. & Katona, I. Neuron 56, 33–42 (2007).
Klausberger, T. & Somogyi, P. Science 321, 53–57 (2008).
Jentsch, T.J. Crit. Rev. Biochem. Mol. Biol. 43, 3–36 (2008).
Jentsch, T.J., Poet, M., Fuhrmann, J.C. & Zdebik, A.A. Annu. Rev. Physiol. 67, 779–807 (2005).
Smith, R.L., Clayton, G.H., Wilcox, C.L., Escudero, K.W. & Staley, K.J. J. Neurosci. 15, 4057–4067 (1995).
Staley, K., Smith, R., Schaack, J., Wilcox, C. & Jentsch, T.J. Neuron 17, 543–551 (1996).
Williams, J.R., Sharp, J.W., Kumari, V.G., Wilson, M. & Payne, J.A. J. Biol. Chem. 274, 12656–12664 (1999).
Rivera, C. et al. Nature 397, 251–255 (1999).
Ben-Ari, Y. Nat. Rev. Neurosci. 3, 728–739 (2002).
Farrant, M. & Kaila, K. Prog. Brain Res. 160, 59–87 (2007).
Rheims, S. et al. J. Neurochem. 110, 1330–1338 (2009).
Houston, C.M., Bright, D.P., Sivilotti, L.G., Beato, M. & Smart, T.G. J. Neurosci. 29, 10416–10423 (2009).
Pitt, S.J., Sivilotti, L.G. & Beato, M. J. Neurosci. 28, 11454–11467 (2008).
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Smart, T. Handling accumulated internal Cl− at inhibitory synapses. Nat Neurosci 13, 1043–1044 (2010). https://doi.org/10.1038/nn0910-1043
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DOI: https://doi.org/10.1038/nn0910-1043