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Wnts blow on NeuroD1 to promote adult neuron production and diversity

NeuroD1 is well known for its role in development. In this issue, two papers collectively show that the Wnt pathway directly activates the transcription factor NeuroD1 to regulate adult neurogenesis and, potentially, neuron diversity.

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Figure 1: Wnts control adult neurogenesis and LINE-1 recombination.

Katie Vicari

References

  1. Zhao, C., Deng, W. & Gage, F.H. Cell 132, 645–660 (2008).

    Article  CAS  Google Scholar 

  2. Lledo, P.M., Alonso, M. & Grubb, M.S. Nat. Rev. Neurosci. 7, 179–193 (2006).

    Article  CAS  Google Scholar 

  3. Suh, H., Deng, W. & Gage, F.H. Annu. Rev. Cell Dev. Biol. published online, doi:10.1146/annurev.cellbio.042308.113256 (8 July 2009).

  4. Kriegstein, A. & Alvarez-Buylla, A. Annu. Rev. Neurosci. 32, 149–184 (2009).

    Article  CAS  Google Scholar 

  5. Ninkovic, J. & Gotz, M. Curr. Opin. Neurobiol. 17, 338–344 (2007).

    Article  CAS  Google Scholar 

  6. Kuwabara, T. et al. Nat. Neurosci. 12, 1097–1105 (2009).

    Article  CAS  Google Scholar 

  7. Gao, Z. et al. Nat. Neurosci. 12, 1090–1092 (2009).

    Article  CAS  Google Scholar 

  8. Muotri, A.R. & Gage, F.H. Nature 441, 1087–1093 (2006).

    Article  CAS  Google Scholar 

  9. Muotri, A.R. et al. Nature 435, 903–910 (2005).

    Article  CAS  Google Scholar 

  10. Lie, D.C. et al. Nature 437, 1370–1375 (2005).

    Article  CAS  Google Scholar 

  11. Bertrand, N., Castro, D.S. & Guillemot, F. Nat. Rev. Neurosci. 3, 517–530 (2002).

    Article  CAS  Google Scholar 

  12. Liu, M. et al. Proc. Natl. Acad. Sci. USA 97, 865–870 (2000).

    Article  CAS  Google Scholar 

  13. Miyata, T., Maeda, T. & Lee, J.E. Genes Dev. 13, 1647–1652 (1999).

    Article  CAS  Google Scholar 

  14. Han, J.S. & Boeke, J.D. Bioessays 27, 775–784 (2005).

    Article  CAS  Google Scholar 

  15. Hirabayashi, Y. et al. Development 131, 2791–2801 (2004).

    Article  CAS  Google Scholar 

Download references

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Vanderhaeghen, P. Wnts blow on NeuroD1 to promote adult neuron production and diversity. Nat Neurosci 12, 1079–1081 (2009). https://doi.org/10.1038/nn0909-1079

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