The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
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Katie Ris
References
Graham, R.K. et al. Cell 125, 1179–1191 (2006).
Gatchel, J.R. & Zoghbi, H.Y. Nat. Rev. Genet. 6, 743–755 (2005).
Ikeda, H. et al. Nat. Genet. 13, 196–202 (1996).
Emamian, E.S. et al. Neuron 38, 375–387 (2003).
Steffan, J.S. et al. Science 304, 100–104 (2004).
Takeyama, K. et al. Neuron 35, 855–864 (2002).
Tsuda, H. et al. Cell 122, 633–644 (2005).
Kim, Y.J. et al. Proc. Natl. Acad. Sci. USA 98, 12784–12789 (2001).
Graham, R.K. et al. Neurobiol. Dis. 21, 444–455 (2006).
Van Raamsdonk, J.M. et al. Hum. Mol. Genet. 14, 3823–3835 (2005).
Klement, I.A. et al. Cell 95, 41–53 (1998).
Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M.E. Cell 95, 55–66 (1998).
Hodgson, J.G. et al. Hum. Mol. Genet. 5, 1875–1885 (1996).
Leavitt, B.R. et al. J. Neurochem. 96, 1121–1129 (2006).
Goehler, H. et al. Mol. Cell 15, 853–865 (2004).
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Fryer, J., Zoghbi, H. Huntingtin's critical cleavage. Nat Neurosci 9, 1088–1089 (2006). https://doi.org/10.1038/nn0906-1088
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DOI: https://doi.org/10.1038/nn0906-1088
