Mice lacking the background potassium channel TREK-1 show elevated activity of serotonergic neurons and behave as if they have been treated with an antidepressant drug, reports a new study. This suggests that the TREK-1 channel may be a good target for the development of drugs for the treatment of depression.
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Gordon, J., Hen, R. TREKing toward new antidepressants. Nat Neurosci 9, 1081–1083 (2006). https://doi.org/10.1038/nn0906-1081
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DOI: https://doi.org/10.1038/nn0906-1081
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