After exocytosis, synaptic vesicles must be retrieved and refilled with neurotransmitter to supply the needs of an active neuron. A new report finds that synaptic activity, through the retrograde action of nitric oxide (NO), regulates the rate of this synaptic vesicle recycling. These findings suggest that NOmight enhance the synaptic strength of coincidentally active neurons.
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Erin Boyle
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Sullivan, J. NO going back. Nat Neurosci 6, 905–906 (2003). https://doi.org/10.1038/nn0903-905
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DOI: https://doi.org/10.1038/nn0903-905
