Abstract
A compartmental nerve–muscle tissue culture system expresses Hebbian1,2 activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.
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Li, MX., Jia, M., Jiang, H. et al. Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity. Nat Neurosci 4, 871–872 (2001). https://doi.org/10.1038/nn0901-871
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DOI: https://doi.org/10.1038/nn0901-871