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From neuron to BOLD: new connections

A recent paper in Nature directly compares fMRI with simultaneously recorded neural activity in the monkey, yielding new insights into the interpretation of BOLD contrast.

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Figure 1: Simultaneous neural and hemodynamic recordings from a cortical site showing transient neural response to a pulse stimulus of 24 seconds.
Figure 2: The BOLD response has larger amplitudes than expected from a linear response to a constant input across stimulus durations.
Figure 3: Normalized response amplitude of LFP, multi-unit activity and BOLD against contrast.


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Correspondence to Peter A. Bandettini or Leslie G. Ungerleider.

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Bandettini, P., Ungerleider, L. From neuron to BOLD: new connections. Nat Neurosci 4, 864–866 (2001).

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