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Brain disorders: getting 'Down' to the gene

Nature Neuroscience volume 13, pages 909–910 (2010)Cite this article

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Narrowing down the genetic basis of Down syndrome, in which hundreds of genes are triplicated, has been difficult. A new study finds that the expression of two affected genes, Olig1 and Olig2, is critical for maintaining the balance of inhibitory and excitatory signaling in a mouse model of Down syndrome.

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Figure 1: Mouse models of Down syndrome are essential tools for identifying genes causing mental retardation in humans.

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  1. The author is in the Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.,

    Lino Tessarollo

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  1. Lino Tessarollo
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Correspondence to Lino Tessarollo.

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Tessarollo, L. Brain disorders: getting 'Down' to the gene. Nat Neurosci 13, 909–910 (2010). https://doi.org/10.1038/nn0810-909

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