Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Beyond migration: Dlx1 regulates interneuron differentiation

Nature Neuroscience volume 8, pages 979–981 (2005)Cite this article

A new paper shows that the transcription factor Dlx1, known to be involved in neuronal migration, is also necessary for interneuron survival. Mice lacking Dlx1 show subtype-specific loss of interneurons, a reduction in inhibitory currents and generalized seizures.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Transcription factor markers of cortical interneuron subgroup development.

References

  1. Wang, X.J., Tegner, J., Constantinidis, C. & Goldman-Rakic, P.S. Proc. Natl. Acad. Sci. USA 101, 1368–1373 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Sarkisian, M.R., Frenkel, M., Li, W., Oborski, J.A. & LoTurco, J.J. Cereb. Cortex 11, 734–743 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Powell, E.M. et al. J. Neurosci. 23, 622–631 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Pillai-Nair, N. et al. J. Neurosci. 25, 4659–4671 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. Erbel-Sieler, C. et al. Proc. Natl. Acad. Sci. USA 101, 13648–13653 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. Schwaller, B. et al. Mol. Cell. Neurosci. 25, 650–663 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Cobos, I. et al. Nat. Neurosci. 8, 1057–1066 (2005).

    Article  Google Scholar 

  8. Yun, K. et al. Development 129, 5029–5040 (2002).

    CAS  PubMed  Google Scholar 

  9. Sestan, N., Artavanis-Tsakonas, S. & Rakic, P. Science 286, 741–746 (1999).

    Article  CAS  PubMed  Google Scholar 

  10. Ding, M. et al. J. Mol. Neurosci. 8, 93–113 (1997).

    Article  CAS  PubMed  Google Scholar 

  11. Zhou, Q.P. et al. Nucleic Acids Res. 32, 884–892 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Anderson, S.A., Classey, J.D., Conde, F., Lund, J.S. & Lewis, D.A. Neuroscience 67, 7–22 (1995).

    Article  CAS  PubMed  Google Scholar 

  13. Fagiolini, M. et al. Science 303, 1681–1683 (2004).

    Article  CAS  PubMed  Google Scholar 

  14. Daviss, S.R. & Lewis, D.A. Psychiatry Res. 59, 81–96 (1995).

    Article  CAS  PubMed  Google Scholar 

  15. Spencer, K.M. et al. Proc. Natl. Acad. Sci. USA 101, 17288–17293 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, 10021, New York, USA

    Carl Wonders & Stewart Anderson

Authors
  1. Carl Wonders
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stewart Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wonders, C., Anderson, S. Beyond migration: Dlx1 regulates interneuron differentiation. Nat Neurosci 8, 979–981 (2005). https://doi.org/10.1038/nn0805-979

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0805-979

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing