Abstract
Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic KATP channel function is crucial to physiological regulation of food intake and body weight.
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Acknowledgements
The Wellcome Trust (grant no. 042726) and Pharmacia & Upjohn supported this work. S.M. is a Pharmacia & Upjohn student, and M.A.S. is a Wellcome Trust Prize student.
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Spanswick, D., Smith, M., Mirshamsi, S. et al. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3, 757–758 (2000). https://doi.org/10.1038/77660
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DOI: https://doi.org/10.1038/77660
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