A study shows that the histone deacetylases HDAC1 and HDAC2 stimulate oligodendrocyte differentiation by antagonizing the inhibitory action of Wnt signaling, linking genetic and epigenetic control of oligodendrocyte development.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Unwrapping Neurotrophic Cytokines and Histone Modification
Cellular and Molecular Neurobiology Open Access 02 March 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kessaris, N., Pringle, N. & Richardson, W.D. Phil. Trans. R. Soc. Lond. B 363, 71–85 (2008).
Copray, S., Huynh, J.L., Sher, F., Casaccia-Bonnefil, P., & Boddeke, E. Glia published online, doi:10.1002/glia.20881 (16 April 2009).
Ye, F. et al. Nat. Neurosci. 12, 829–838 (2009).
Haberland, M., Montgomery, R.L. & Olson, E. N. Nat. Rev. Genet. 10, 32–42 (2009).
Shen, S., Li, J. & Casaccia-Bonnefil, P. J. Cell Biol. 169, 577–589 (2005).
Shen, S. et al. Nat. Neurosci. 11, 1024–1034 (2008).
Popko, B. Nat. Neurosci. 11, 987–988 (2008).
Kao, H.Y. et al. Genes Dev. 12, 2269–2277 (1998).
Sekiya, T. & Zaret, K.S. Mol. Cell 28, 291–303 (2007).
Shimizu, T. et al. Dev. Biol. 282, 397–410 (2005).
Clevers, H. Cell 127, 469–480 (2006).
Fancy, S.P.J. & Rowitch, D.H. Genes Dev. published online, doi:10.1101/gad.1806309 (1 July 2009).
Genoud, S. et al. J. Cell Biol. 158, 709–718 (2002).
Liu, A. et al. EMBO J. 25, 4833–4842 (2006).
John, G.R. et al. Nat. Med. 8, 1115–1121 (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, H., Richardson, W. Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration. Nat Neurosci 12, 815–817 (2009). https://doi.org/10.1038/nn0709-815
Issue Date:
DOI: https://doi.org/10.1038/nn0709-815
This article is cited by
-
Unwrapping Neurotrophic Cytokines and Histone Modification
Cellular and Molecular Neurobiology (2017)
-
Epigenetics of Multiple Sclerosis: An Updated Review
NeuroMolecular Medicine (2015)
-
Polydendrocytes in development and myelin repair
Neuroscience Bulletin (2013)