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Numb, neurogenesis and epithelial polarity

Numb's function in mammalian neural progenitors has been unclear. A paper in this issue shows a crucial role for Numb in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.

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Figure 1: Numb localization is evolutionarily conserved in fly neuroblast and mammalian neuroepithelium.

Kim Caesar

References

  1. 1

    Noctor, S.C., Flint, A.C., Weissman, T.A., Dammerman, R.S. & Kriegstein, A.R. Nature 409, 714–720 (2001).

    CAS  Article  Google Scholar 

  2. 2

    Rasin, M.-R. et al. Nat. Neurosci. 10, 819–827 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Li, H.S. et al. Neuron 40, 1105–1118 (2003).

    CAS  Article  Google Scholar 

  4. 4

    Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N. & Zhong, W. Nature 419, 929–934 (2002).

    CAS  Article  Google Scholar 

  5. 5

    Petersen, P.H., Zou, K., Krauss, S. & Zhong, W. Nat. Neurosci. 7, 803–811 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Wodarz, A. Curr. Opin. Cell Biol. 17, 475–481 (2005).

    CAS  Article  Google Scholar 

  7. 7

    Kuo, C.T. et al. Cell 127, 1253–1264 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. & Jan, Y.N. Neuron 17, 43–53 (1996).

    CAS  Article  Google Scholar 

  9. 9

    Smith, C.A. et al. EMBO J. 26, 468–480 (2007).

    CAS  Article  Google Scholar 

  10. 10

    Wakamatsu, Y., Maynard, T.M., Jones, S.U. & Weston, J.A. Neuron 23, 71–81 (1999).

    CAS  Article  Google Scholar 

  11. 11

    Zhou, Y. et al. Cell 129, 163–178 (2007).

    CAS  Article  Google Scholar 

  12. 12

    Berdnik, D., Torok, T., Gonzalez-Gaitan, M. & Knoblich, J.A. Dev. Cell 3, 221–231 (2002).

    CAS  Article  Google Scholar 

  13. 13

    Lien, W.H., Klezovitch, O., Fernandez, T.E., Delrow, J. & Vasioukhin, V. Science 311, 1609–1612 (2006).

    CAS  Article  Google Scholar 

  14. 14

    Chenn, A. & Walsh, C.A. Science 297, 365–369 (2002).

    CAS  Article  Google Scholar 

  15. 15

    Cappello, S. et al. Nat. Neurosci. 9, 1099–1107 (2006).

    CAS  Article  Google Scholar 

Download references

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Kim, S., Walsh, C. Numb, neurogenesis and epithelial polarity. Nat Neurosci 10, 812–813 (2007). https://doi.org/10.1038/nn0707-812

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