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Nitro-PDI incites toxic waste accumulation

Nature Neuroscience volume 9, pages 865–867 (2006)Cite this article

In Parkinson disease and related disorders, nitric oxide may disable PDI, an enzyme critical for proper protein folding in the endoplasmic reticulum, resulting in the accumulation of damaged proteins and eventually neuronal death.

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Figure 1: Involvement of nitric oxide (NO)-mediated modification of protein disulfide isomerase (PDI) in the accumulation of neurotoxic proteins in Parkinson disease.

Jessica Iannuzzi

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  1. Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, 21224, Maryland, USA

    Mark P Mattson

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  1. Mark P Mattson
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Mattson, M. Nitro-PDI incites toxic waste accumulation. Nat Neurosci 9, 865–867 (2006). https://doi.org/10.1038/nn0706-865

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