NMDA receptors lose their inhibitions

A new study suggests that interactions between dopamine and glutamate neurotransmitter pathways are important in regulating the inhibitory effects of alcohol on brain function.

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Figure 1: Intracellular molecular events linking dopamine receptor activation to increased NMDA receptor phosphorylation and decreased inhibition by alcohol.

Ivelisse Robles

References

  1. 1

    Diamond, I. & Gordon, A. S. Physiol. Rev. 77, 1–20 (1997).

  2. 2

    Pennartz, C.M., Ameerun, R., Groenewegen, H. & Lopes da Silva, F.H. Eur. J. Neurosci. 5, 107–117 (1993).

  3. 3

    Kombian, S.B. & Malenka, R.C. Nature 368, 242–246 (1994).

  4. 4

    Maldve, R.E. et al. Nat. Neurosci. 5, 641–648 (2002).

  5. 5

    Snyder, G.L. et al. J. Neurosci. 18, 10297–10303 (1998).

  6. 6

    Edwards, S. et al. Alcohol. Clin. Exp. Res. 26, 173–180 (2002).

  7. 7

    El-Ghundi, M. et al. Eur. J. Pharmacol. 353, 149–158 (1998).

  8. 8

    Risinger, F.O. et al. J. Neurosci. 21, 340–348 (2001).

  9. 9

    Brodie, M.S., Shefner, S.A. & Dunwiddie, T.V. Brain Res. 508, 65–69 (1990).

  10. 10

    Gessa, G.L. et al. Brain Res. 348, 201–203 (1985).

  11. 11

    Gonzales, R.A. & Weiss, F. J. Neurosci. 18, 10633–10671 (1998).

  12. 12

    Miyakawa, T. et al. Science 278, 698–701 (1997).

  13. 13

    Lovinger, D.M. J. Pharmacol. Exp. Ther. 274, 164–172 (1995).

  14. 14

    Yang, X. et al. J. Pharmacol. Exp. Ther. 278, 114–124 (1996).

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Lovinger, D. NMDA receptors lose their inhibitions. Nat Neurosci 5, 614–616 (2002). https://doi.org/10.1038/nn0702-614

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