Brief Communication | Published:

Alternative role for prolactin-releasing peptide in the regulation of food intake

Nature Neuroscience volume 3, pages 645646 (2000) | Download Citation

Subjects

Abstract

Prolactin-releasing peptide (PrRP) is a peptide ligand for the human orphan G-protein-coupled receptor hGR3/GPR10 and causes the secretion of prolactin from anterior pituitary cells1. However, the lack of immunoreactive staining for PrRP in the external layer of the median eminence seems to rule out this peptide as a classical hypophysiotropic hormone2,3,4 and, furthermore, PrRP is less effective than another inducer of prolactin secretion, thyrotropin-releasing hormone, both in vitro and in vivo5,6,7. Here we show a reduction in the expression of PrRP mRNA during lactation and fasting and an acute effect of PrRP on food intake and body weight, supporting the hypothesis of an alternative role for the peptide.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature 393, 272–276 (1998).

  2. 2.

    et al. Neuroreport 10, 1713–1716 (1999).

  3. 3.

    et al. Endocrinology 140, 2326–2333 (1999).

  4. 4.

    , , & Neurosci. Lett. 267, 113–116 (1999).

  5. 5.

    et al. Biochem. Biophys. Res. Commun. 259, 321–324 (1999).

  6. 6.

    , , & Endocrine 9, 289–291 (1998).

  7. 7.

    et al. Neurosci. Lett. 276, 103–106 (1999).

  8. 8.

    et al. Endocrinology 140, 5736–5745 (1999).

  9. 9.

    , & Neuropeptides 33, 387–399 (1999).

  10. 10.

    et al. J. Neurosci 20, 1616–1621 (2000).

  11. 11.

    , & Neuron 22, 221–232 (1999).

  12. 12.

    & Brain Res. 851, 66–75 (1999).

  13. 13.

    , , & Neuroendocrinology 52, 441–447 (1990).

  14. 14.

    et al. Nature 393, 72–76 (1998).

Download references

Acknowledgements

We acknowledge the support of the Biotechnology and Biosciences Research Council and AstraZeneca plc. We also thank N. Rothwell and A. Turnbull for commenting on the manuscript and A. Hardwick for technical assistance.

Author information

Affiliations

  1. School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT UK

    • Catherine B. Lawrence
    • , Fulvio Celsi
    •  & Simon M. Luckman
  2. AstraZeneca, Mereside, Alderley Edge, Cheshire SK10 4TQ UK

    • John Brennand

Authors

  1. Search for Catherine B. Lawrence in:

  2. Search for Fulvio Celsi in:

  3. Search for John Brennand in:

  4. Search for Simon M. Luckman in:

Corresponding author

Correspondence to Simon M. Luckman.

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/76597

Further reading