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What does the habenula tell dopamine neurons?

Nature Neuroscience volume 10, pages 677–678 (2007)Cite this article

Reward-related events activate dopamine and other neurons in many brain areas. A report in Nature, however, now suggests that neurons in the lateral habenula signal to dopamine neurons when no reward is expected.

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Figure 1: Anatomical locations of primate lateral habenula and dopamine neurons and specific signals that they transmit during saccadic eye movements for large and small rewards.

References

  1. Schultz, W. Neuron 36, 241–263 (2002).

    Article  CAS  Google Scholar 

  2. Satoh, T., Nakai, S., Sato, T. & Kimura, M. J. Neurosci. 23, 9913–9923 (2003).

    Article  CAS  Google Scholar 

  3. Morris, G., Arkadir, D., Nevet, A., Vaadia, E. & Bergman, H. Neuron 43, 133–143 (2004).

    Article  CAS  Google Scholar 

  4. Sutton, R.S. & Barto, A.G. Reinforcement Learning (MIT Press, Cambridge, Massachusetts, 1998).

    Google Scholar 

  5. Montague, P.R., Hyman, S.E. & Cohen, J.D. Nature 431, 760–767 (2004).

    Article  CAS  Google Scholar 

  6. Reynolds, J.N., Hyland, B.I. & Wickens, J.R. Nature 413, 67–70 (2001).

    Article  CAS  Google Scholar 

  7. Calabresi, P., Picconi, B., Tozzi, A. & Di Filippo, M. Trends Neurosci. 30, 211–219 (2007).

    Article  CAS  Google Scholar 

  8. Matsumoto, M. & Hikosaka, O. Nature, advance online publication 23 May 2007 (doi:10.1038/nature05860).

    Article  CAS  Google Scholar 

  9. Parent, A., Gravel, S. & Boucher, R. Brain Res. Bull. 6, 23–38 (1981).

    Article  CAS  Google Scholar 

  10. Herkenham, M. & Nauta, W.J. J. Comp. Neurol. 187, 19–47 (1979).

    Article  CAS  Google Scholar 

  11. Christoph, G.R., Leonzio, R.J. & Wilcox, K.S. J. Neurosci. 6, 613–619 (1986).

    Article  CAS  Google Scholar 

  12. Hikosaka, O., Takikawa, Y. & Kawagoe, R. Physiol. Rev. 80, 953–978 (2000).

    Article  CAS  Google Scholar 

  13. Wang, R.Y. & Aghajanian, G.K. Science 197, 89–91 (1977).

    Article  CAS  Google Scholar 

  14. Ungless, M.A., Magill, P.J. & Bolam, J.P. Science 303, 2040–2042 (2004).

    Article  CAS  Google Scholar 

  15. Gao, D.M., Hoffman, D. & Benabid, A.L. Eur. J. Neurosci. 8, 1474–1478 (1996).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Minoru Kimura and Naoyuki Matsumoto are in the Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. mkimura@koto.kpu-m.ac.jp,

    Minoru Kimura & Naoyuki Matsumoto

  2. Takemasa Satoh is in the Division of Neurobiology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.,

    Takemasa Satoh

Authors
  1. Minoru Kimura
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  2. Takemasa Satoh
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  3. Naoyuki Matsumoto
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Kimura, M., Satoh, T. & Matsumoto, N. What does the habenula tell dopamine neurons?. Nat Neurosci 10, 677–678 (2007). https://doi.org/10.1038/nn0607-677

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