During development, neurons destined for different neocortical layers are sequentially generated. Shen et al. report that this timing is programmed within individual progenitor cells and depends mainly on cell-intrinsic mechanisms.
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Mizutani, Ki., Gaiano, N. Chalk one up for 'nature' during neocortical neurogenesis. Nat Neurosci 9, 717–718 (2006). https://doi.org/10.1038/nn0606-717
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DOI: https://doi.org/10.1038/nn0606-717