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How inflammation promotes regeneration

Nature Neuroscience volume 9, pages 715–717 (2006)Cite this article

Macrophages near neuronal cell bodies can promote regeneration in an otherwise inhibitory environment. Now Yin et al. identify oncomodulin as a factor secreted from macrophages that promotes extensive regeneration of lesioned optic nerve axons when applied together with elevated cyclic AMP (cAMP) and mannose.

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Figure 1: Schematic representation of the number of axons and the distance they regenerated after the various treatments.

Jessica Iannuzzi

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  1. Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, 10021, New York, USA

    Marie T Filbin

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  1. Marie T Filbin
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Filbin, M. How inflammation promotes regeneration. Nat Neurosci 9, 715–717 (2006). https://doi.org/10.1038/nn0606-715

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