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Designer genes and anti-anxiety drugs

Anxiolytic-like and sedative effects of benzodiazepines can be dissociated in mice with a mutant GABAA receptor α1 subunit gene or in wild-type mice by a new benzodiazepine-site ligand.

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Figure 1: Contribution of α1 subunit-containing GABAA receptors to the effects of benzodiazepine-site ligands.

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Tecott, L. Designer genes and anti-anxiety drugs. Nat Neurosci 3, 529–530 (2000). https://doi.org/10.1038/75692

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