Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Exocytosis: meltdown of the core

Abstract

Betz and colleagues find that dopamine triggers release of the dense core of secretory granules with prolactin during exocytosis. The dense core can contain signaling proteins, implying that both the quality and the quantity of released material can be regulated.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Exocytosis of dense-core vesicle and endocytosis that follows.

References

  1. Angleson, J. K., Cochilla, A. J., Kilic, G., Nussinovitch, I. & Betz, W. J. Nat. Neurosci. 2, 440–446 (1999).

    Article  CAS  Google Scholar 

  2. Huttner, W. B., Gerdes, H. H. & Rosa, P. Trends Biochem. Sci. 16, 27–30 (1991).

    Article  CAS  Google Scholar 

  3. Laslop, A. et al. J. Neurochem. 70, 374–383 (1998).

    Article  CAS  Google Scholar 

  4. Mahata, S. K. et al. J. Clin. Invest. 100, 1623–1633 (1997).

    Article  CAS  Google Scholar 

  5. Yoo, S. H. & Kang, Y. K. 406, 259–262 (1997).

  6. Aspinwall, C. A., Brooks, S. A., Kennedy, R. T. & Lakey, J. R. J. Biol. Chem. 272, 31308–31314 (1997).

    Article  CAS  Google Scholar 

  7. Han, W., Li, D., Stout, A. K., Takimoto, K. & Levitan, E. S. J. Neurosci. 19, 900–905 (1999).

    Article  CAS  Google Scholar 

  8. Lee, C. J., Dayanithi, G., Nordmann, J. J. & Lemos, J. R. Neuron 8, 335–342 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stevens, C. Exocytosis: meltdown of the core. Nat Neurosci 2, 391–392 (1999). https://doi.org/10.1038/8050

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/8050

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing