Over the last six years, Nature has launched four 'sister' journals that carry the Nature name. Each has become a leading journal in its respective field, and encouraged by this success we are now adding Nature Neuroscience to the family. Why neuroscience, and why now?

One reason is the rapid expansion of the field. A prominent sign of this is the size and growth of the Society for Neuroscience; over the last decade its membership has more than doubled, and it is now a worldwide organization with over 27,000 members. The trend seems likely to continue; President Clinton's budget request for 1999 includes a large increase for basic research, and neuroscience has been identified by the Department of Health & Human Services (which funds NIH) as an area of special promise and significance. Other countries are also giving high priority to neuroscience research, motivated in part by the immense costs of mental illness and by the economic implications of cognitive decline in their growing populations of elderly citizens.

Not only is neuroscience a large field, it is also exceptionally diverse. The range of questions it seeks to answer is paralleled only by the range of techniques it employs, from the creation of transgenic animals to functional brain imaging to the modeling of neural networks by ever-more powerful computers. This diversity presents a problem; with so many disciplines using different technologies and speaking different jargon, communication is not always easy. But there are compelling reasons to make the effort, as modern neuroscience becomes increasingly interdisciplinary. For instance, molecular and systems neuroscience are now inextricably related; the phenotypes created by gene knock-out techniques can often be understood only through a knowledge of the brain circuits they affect, while systems neuroscientists are becoming increasingly aware of the enormous power of the tools that molecular biology has placed at their disposal. Cognitive neuroscientists and psychologists are also paying increasing attention to systems neuroscience, as physiological data from diverse species provide new insights into the neural basis of human mental processes.

Perhaps more than any other field of biology, neuroscience still has a 'frontier' feel to it. The vast complexity of the brain represents the ultimate challenge to molecular and developmental biologists; nevertheless, progress in this area is rapid, and there is reason to hope that we shall understand the molecular basis for such fundamental processes as axon guidance and synapse formation within the foreseeable future. The modification of synaptic strength may also hold the key to the formation and storage of memories, but the problem of memory goes deeper than this; cognitive neuroscientists have identified many different forms of memory, and even if they share the same cellular mechanisms (which remains to be determined), they have fundamentally different properties, which must surely arise from the architecture of the different brain systems involved. Other fundamental questions are still hotly debated; one prominent example is the extent to which neural information is encoded in the precise timing of spikes. And the neural basis of higher functions, including perception, movement and emotion, let alone language and thought, is only beginning to be explored.

We believe that the scope and promise of the neuroscience research enterprise represent ample justification for the launch of Nature Neuroscience. But the sheer size of the field also presents a challenge. In 1997 alone, the Index Medicus lists over 26,000 papers with "brain" as their subject; clearly no journal, indeed no reader, can possibly expect to achieve comprehensive coverage of modern brain research. Rather, our aim is to publish a relatively small number of papers of exceptional significance and quality, drawn from all areas of neuroscience, as examples of what seems to us most interesting, significant, intellectually stimulating, even entertaining. We do not intend to replace any existing journal, but we believe, based on the advice of many neuroscientists, that there is a real need for a new forum where different disciplines can come together and exchange ideas. We hope to provide such a forum, by presenting the best papers in every discipline from molecular neurobiology to psychophysics, so that interested readers can get a clearer picture of the activities of the field as a whole.

Papers in Nature Neuroscience will typically be somewhat longer than those in Nature itself, but they will still be relatively short. Busy scientists value brevity as well as clarity, particularly when reading outside their own immediate area of research, and we aim that our papers should be clear and accessible to the widest possible range of readers. We shall not hesitate to remind authors when their own manuscripts fall short in this respect; we hope that the end will justify the means, and we encourage readers to let us know how we are doing.

A word about our relationship to Nature is in order. Like our parent journal, we shall place high priority on rapid editorial decisions and publication. We shall strive for accessibility to a broad readership, and in particular we hope that our News and Views section, which is closely modeled on Nature 's, will help to achieve this goal. We shall also be editorially independent in the sense of having no external editorial board. Instead, editorial decisions are made by our full-time editorial staff, consulting with outside experts as we see fit. This is a longstanding policy for both Nature and the monthly Nature titles; it has served us well over the years, allowing editorial flexibility and ensuring that the opinions of a particular individual or group do not dominate editorial policy in any given field.

Despite sharing much in common, the two journals are editorially independent of each other. Thus, it will be for the authors alone to decide where to submit their manuscripts, and Nature will not divert papers to Nature Neuroscience unless the authors explicitly request this. Nature itself will continue to cover the most significant advances in neuroscience as it has always done, and it will judge the manuscripts it receives on their merits, without the involvement of Nature Neuroscience. If, however, a paper cannot be accepted by Nature, authors are welcome to resubmit to Nature Neuroscience. Nature will then release the referees' comments to the editors of Nature Neuroscience, thereby facilitating a rapid editorial decision.

This first issue provides an illustration of the diversity we hope to achieve. The Research Articles cover the spectrum from molecules to cognition, and are arranged in roughly ascending order from low-level to high-level questions. The Scientific Correspondence section (which is fully peer-reviewed) is intended for shorter items that are nevertheless of broad interest to the neuroscience community. The News and Views section is intended to highlight a particular paper (or group of papers on a single theme) and to put the findings in a broader context for non-specialist readers. Most will be devoted to papers appearing in Nature Neuroscience itself, but some (see for instance page 8) will focus on papers of exceptional significance that appear elsewhere. We welcome suggestions for such unlinked pieces, and authors need not be shy about alerting us to their own forthcoming publications in other journals. We also plan to publish reviews on a regular basis, and again we shall be happy to consider suggestions and offers. In the near future, we plan to add Book Reviews and a section for Letters to the editor; the latter may be on matters arising from our previous publications, or on any other topic of interest to our readership.

The problems that neuroscience addresses are almost unique in their scope, and the implications for society are similarly broad. Not only does it hold the promise of new treatments for mental illness, drug addiction, neurodegeneration, cognitive decline with age; neuroscience can also speak—as yet, tentatively—to issues such as education, crime, personality, and to the interplay between cultural environment and biological nature that gives rise to our own mental lives. And finally there is the question of how we came to be here at all; how evolution, that is natural selection acting on sequences of DNA, gave rise to awareness, emotion, intelligence. These are grand themes, and it is easy to forget them when preoccupied with planning the next experiment, writing the next funding application, or for that matter preparing the next issue of a journal. But we should nevertheless remind ourselves occasionally that it is the promise of illuminating such questions that makes the nervous system a uniquely fascinating object of study. Nature Neuroscience looks forward to capturing some of that fascination in the months and years ahead.

Finally, Nature Neuroscience will be published both on paper and electronically; those who are reading this in print are invited to visit our web site (https://doi.org/neurosci.nature.com), where the text of this entire issue will be freely available from 1 May. We welcome your feedback, and hope that you will find Nature Neuroscience an interesting and valuable source of information.