The ephrin subclasses A and B are not thought to interact much with each other's receptors. A study in this issue now shows that ephrin-A5 can signal through the EphB2 receptor, toppling this dogma. The crystal structure of the EphB2–ephrin-A5 complex clarifies the molecular features of this interaction and suggests new hypotheses for the mechanism of ephrin receptor signaling.
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Pasquale, E. Eph–ephrin promiscuity is now crystal clear. Nat Neurosci 7, 417–418 (2004). https://doi.org/10.1038/nn0504-417
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DOI: https://doi.org/10.1038/nn0504-417
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