NMDA receptors are important for both normal transmission and pathological damage. New results indicate that receptor location makes the key difference: survival-promoting signals derive from synaptic receptors, whereas a cell-death signal comes from extrasynaptic receptors.
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Riccio, A., Ginty, D. What a privilege to reside at the synapse: NMDA receptor signaling to CREB. Nat Neurosci 5, 389–390 (2002). https://doi.org/10.1038/nn0502-389
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DOI: https://doi.org/10.1038/nn0502-389
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