Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BMPs: time to murder and create?

Nature Neuroscience volume 2, pages 301–303 (1999)Cite this article

Abstract

The olfactory epithelium produces new neurons throughout life. Shou et al. show that BMPs can inhibit this process by inducing degradation of the transcription factor MASH1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Role of BMP signaling in development of olfactory and sympathetic neuronal lineages.

References

  1. Graziadei, P. P. & Graziadei, G. A. J. Neurocytol. 8, 1–18 (1979).

    Article  CAS  Google Scholar 

  2. Calof, A. L., Mumm, J. S., Rim, P. C. & Shou, J. J. Neurobiol. 36, 190–205 (1998).

    Article  CAS  Google Scholar 

  3. Schwartz-Levey, S., Chikaraishi, D. M. & Kauer, J. S. J. Neurosci. 11, 3556– 3564 (1991).

    Article  CAS  Google Scholar 

  4. Holcomb, J. D., Mumm, J. S. & Calof, A. L. Dev. Biol. 172, 307– 323 (1995).

    Article  CAS  Google Scholar 

  5. Hogan, B. L. Genes Dev. 10, 1580–1594 (1996).

    Article  CAS  Google Scholar 

  6. Mumm, J. S., Shou, J. & Calof, A. L. Proc. Natl. Acad. Sci. USA 93, 11167–11172 (1996).

    Article  CAS  Google Scholar 

  7. Cau, E., Gradwohl, G., Fode, C. & Guillemot, F. Development 124, 1611–1621 (1997).

    CAS  PubMed  Google Scholar 

  8. Guillemot, F. et al. Cell 75, 463–476 (1993).

    Article  CAS  Google Scholar 

  9. Shah, N. M., Grove, A. & Anderson, D. J. Cell 85, 331– 343 (1996).

    Article  CAS  Google Scholar 

  10. Anderson, D. J. & Jan, Y. N. in Molecular and Cellular Approaches to Neural Development (eds. Cowan, W. M., Jessell, T. M. & Zipursky, S. L.) 26–63 (Oxford Univ. Press, New York, 1997).

    Google Scholar 

  11. Gordon, M. K., Mumm, J. S., Davis, R., Holcomb, J. D. & Calof, A. L. Mol. Cell. Neurosci. 6, 363–379 (1995).

    Article  CAS  Google Scholar 

  12. Lo, L., Johnson, J. E., Wuenschell, C. W., Saito, T. & Anderson, D. J. Genes Dev. 5, 1524–1537 (1991).

    Article  CAS  Google Scholar 

  13. Lo, L., Sommer, L. & Anderson, D. J. Curr. Biol. 7, 440– 450 (1997).

    Article  CAS  Google Scholar 

  14. Lo, L., Tiveron, M.-C. & Anderson, D. J. Development 125, 609– 620 (1998).

    CAS  PubMed  Google Scholar 

  15. Casarosa, S., Fode, C. & Guillemot, F. Development 126, 525– 534 (1999).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Developmental Genetics Program, The Skirball Institute, NYU Medical Center, 540 First Ave., 4th Floor, Lab 7, New York, 10016, New York, USA

    Gordon Fishell

Authors
  1. Gordon Fishell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fishell, G. BMPs: time to murder and create?. Nat Neurosci 2, 301–303 (1999). https://doi.org/10.1038/7208

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/7208

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing