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Proteoglycans specify Sonic Hedgehog effect

Nature Neuroscience volume 12, pages 371–372 (2009)Cite this article

How can the multifunctional factor Sonic Hedgehog (SHH) elicit specific responses from its target cells? A study now pinpoints proteoglycans as crucial anchors and modulators of SHH signaling, eliciting a proliferation response.

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Figure 1: SHH binding to heparan sulfate proteoglycans elicits a proliferative response.

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Authors and Affiliations

  1. Department of Biomedicine, Catherine Vaillant is a member of the Developmental Genetics group, University of Basel, Basel, Switzerland. c.vaillant@unibas.ch,

    Catherine Vaillant

  2. Denis Monard is at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. monard@fmi.ch,

    Denis Monard

Authors
  1. Catherine Vaillant
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  2. Denis Monard
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Vaillant, C., Monard, D. Proteoglycans specify Sonic Hedgehog effect. Nat Neurosci 12, 371–372 (2009). https://doi.org/10.1038/nn0409-371

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