News & Views | Published:

Fine control: microRNA regulation of adult neurogenesis

Nature Neuroscience volume 12, pages 369370 (2009) | Download Citation

Subjects

Neural stem cells transition through several progenitor stages before finally generating postmitotic neurons. New work shows that one of these steps, the generation of neuroblasts from transient amplifying precursors in the adult subventricular zone, requires downregulation of the transcription factor Sox9 by the microRNA miR-124.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , & Nat. Neurosci. 12, 399–408 (2009).

  2. 2.

    & Neuron 41, 683–686 (2004).

  3. 3.

    , , & Epigenetic mechanisms regulating fate specification of neural stem cells. Philos. Trans. R Soc. Lond. B Biol. Sci. 363, 2099–2109 (2008).

  4. 4.

    & Science 319, 1789–1790 (2008).

  5. 5.

    et al. Curr. Biol. 12, 735–739 (2002).

  6. 6.

    Mol. Pharmacol. 75, 259–264 (2009).

  7. 7.

    , , , & Genes Dev. 21, 744–749 (2007).

  8. 8.

    , & Genes Dev. 21, 531–536 (2007).

  9. 9.

    , & Proc. Natl. Acad. Sci. USA 96, 11619–11624 (1999).

  10. 10.

    et al. Genes Dev. 17, 1677–1689 (2003).

  11. 11.

    , , & Cell Stem Cell 3, 33–43 (2008).

  12. 12.

    et al. J. Cell Biol. 178, 635–648 (2007).

  13. 13.

    et al. Nature 433, 769–773 (2005).

  14. 14.

    & Nat. Rev. Genet. 5, 396–400 (2004).

  15. 15.

    , , & Proc. Natl. Acad. Sci. USA 103, 2422–2427 (2006).

Download references

Author information

Affiliations

  1. New York Neural Stem Cell Institute, Rensselaer, New York, USA. qinshen@nynsci.org or sallytemple@nynsci.org

    • Qin Shen
    •  & Sally Temple

Authors

  1. Search for Qin Shen in:

  2. Search for Sally Temple in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nn0409-369

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing