How does the binding of agonist lead to a change in ion channel gating? Kohda and colleagues take advantage of the lurcher mutation to provide new insights into how binding of glutamate affects channel gating for AMPA, kainate and NMDA receptors.
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Krupp, J., Westbrook, G. An orphan glutamate channel points the way to the gates. Nat Neurosci 3, 301–302 (2000). https://doi.org/10.1038/73846
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DOI: https://doi.org/10.1038/73846
