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Notch keeps ependymal cells in line

Nature Neuroscience volume 12, pages 243–245 (2009)Cite this article

The ependymal cells lining the lateral ventricles are not stem cells, but a study now shows that they can be activated to generate neuroblasts in a stroke model, and mature olfactory bulb neurons when Notch signaling is disrupted.

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Figure 1: Ependymal cells switch to a different fate after stroke.

Kim Caesar

References

  1. Johansson, C.B. et al. Cell 96, 25–34 (1999).

    Article  CAS  Google Scholar 

  2. Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Cell 97, 703–716 (1999).

    Article  CAS  Google Scholar 

  3. Consiglio, A. et al. Proc. Natl. Acad. Sci. USA 101, 14835–14840 (2004).

    Article  CAS  Google Scholar 

  4. Capela, A. & Temple, S. Neuron 35, 865–875 (2002).

    Article  Google Scholar 

  5. Carlén et al. Nat. Neurosci. 12, 259–267 (2009).

    Article  Google Scholar 

  6. Mirzadeh, Z., Merkle, F.T., Soriano-Navarro, M., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Cell Stem Cell 3, 265–278 (2008).

    Article  CAS  Google Scholar 

  7. Coskun, V. et al. Proc. Natl. Acad. Sci. USA 105, 1026–1031 (2008).

    Article  CAS  Google Scholar 

  8. Kohyama, J. et al. Proc. Natl. Acad. Sci. USA 105, 18012–18017 (2008).

    Article  CAS  Google Scholar 

  9. Jessberger, S., Toni, N., Clemenson, G.D. Jr., Ray, J. & Gage, F.H. Nat. Neurosci. 11, 888–893 (2008).

    Article  CAS  Google Scholar 

  10. Yu, J. et al. Science 318, 1917–1920 (2007).

    Article  CAS  Google Scholar 

  11. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  Google Scholar 

  12. Kuhn, H.G., Dickinson-Anson, H. & Gage, F.H. J. Neurosci. 16, 2027–2033 (1996).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, 92037, California, USA

    Chunmei Zhao, Hoonkyo Suh & Fred H Gage

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  1. Chunmei Zhao
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  2. Hoonkyo Suh
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  3. Fred H Gage
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Zhao, C., Suh, H. & Gage, F. Notch keeps ependymal cells in line. Nat Neurosci 12, 243–245 (2009). https://doi.org/10.1038/nn0309-243

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