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Rett syndrome: what do we know for sure?

Rett syndrome (RTT) is caused by mutations in the X-linked gene encoding methyl CpG–binding protein (MeCP2). The loss of MeCP2 function in neurons was thought to cause the disease. A study now challenges this assumption by showing that MeCP2 is expressed in glia and that MeCP2 loss in glia causes abnormalities in neighboring neurons.

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Figure 1: Mecp2−/− astrocytes secrete a factor that is toxic to neurons.

Kim Caesar

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Zoghbi, H. Rett syndrome: what do we know for sure?. Nat Neurosci 12, 239–240 (2009). https://doi.org/10.1038/nn0309-239

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