How does axonal loss, a hallmark of multiple sclerosis, occur? A study in this issue implicates histone deacetylase 1 (HDAC1), better known for regulating DNA transcription, in such axon degeneration. HDAC1 is exported from the nucleus and interacts with motor proteins, blocking axonal transport and leading to axon loss.
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Miller, R. Renegade nuclear enzymes disrupt axonal integrity. Nat Neurosci 13, 143–144 (2010). https://doi.org/10.1038/nn0210-143
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DOI: https://doi.org/10.1038/nn0210-143
