The Cav1.3 calcium channel is found on striatopallidal neurons expressing the D2 dopamine receptor. A new study finds that in an animal model of Parkinson disease, this channel is involved in degeneration of dendritic spines on striatal projection neurons.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor
Cell and Tissue Research Open Access 15 June 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Albin, R.L., Young, A.B. & Penney, J.B. Trends Neurosci. 12, 366–375 (1989).
DeLong, M.R. Trends Neurosci. 13, 281–285 (1990).
Gerfen, C.R. et al. Science 250, 1429–1432 (1990).
Bergman, H., Wichmann, T. & DeLong, M.R. Science 249, 1436–1438 (1990).
Day, M. et al. Nat. Neurosci. 9, 251–259 (2006).
McNeill, T.H., Brown, S.A., Rafols, J.A. & Shoulson, I. Brain Res. 455, 148–152 (1988).
Ingham, C.A., Hood, S.H. & Arbuthnott, G.W. Brain Res. 503, 334–338 (1989).
Ingham, C.A., Hood, S.H., Taggart, P. & Arbuthnott, G.W. J. Neurosci. 18, 4732–4743 (1998).
Heintz, N. Nat. Rev. Neurosci. 2, 861–870 (2001).
Gong, S. et al. Nature 425, 917–925 (2003).
Olson, P.A. et al. J. Neurosci. 25, 1050–1062 (2005).
Hernandez-Lopez, S. et al. J. Neurosci. 20, 8987–8995 (2000).
Bergman, H. et al. Trends Neurosci. 21, 32–38 (1998).
Zheng, T. & Wilson, C.J. J. Neurophysiol. 87, 1007–1017 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gerfen, C. Indirect-pathway neurons lose their spines in Parkinson disease. Nat Neurosci 9, 157–158 (2006). https://doi.org/10.1038/nn0206-157
Issue Date:
DOI: https://doi.org/10.1038/nn0206-157
This article is cited by
-
The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats
Anatomical Science International (2023)
-
Integrative Functions of the Cortico-Strio-Thalamo-Cortical System of the Brain
Neuroscience and Behavioral Physiology (2022)
-
Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor
Cell and Tissue Research (2020)
-
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences
Nature Neuroscience (2014)
-
Vasoactive Intestinal Peptide (VIP) Treatment of Parkinsonian Rats Increases Thalamic Gamma-Aminobutyric Acid (GABA) Levels and Alters the Release of Nerve Growth Factor (NGF) by Mast Cells
Journal of Molecular Neuroscience (2010)