The exact embryonic origins of forebrain oligodendrocytes have been unclear. A new study addresses the question with elegant genetic fate mapping, and concludes that oligodendrocytes are generated in three distinct waves. Oligodendrocytes from later waves eventually replaced those generated in earlier waves, but if one wave was lost, the other waves could compensate.
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Jessica Iannuzzi
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Ventura, R., Goldman, J. Telencephalic oligodendrocytes battle it out. Nat Neurosci 9, 153–154 (2006). https://doi.org/10.1038/nn0206-153
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DOI: https://doi.org/10.1038/nn0206-153
