Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Orphan nuclear receptors control neuronal remodeling during fly metamorphosis

Nature Neuroscience volume 14, pages 6–7 (2011)Cite this article

Subjects

Pruning of excess branches is essential for the maturation of developing neuronal circuits. Cross-talk between TGF-β signaling and two antagonistic orphan nuclear receptors governs the pruning of larval γ neurons in the Drosophila pupa.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic model of axon pruning during Drosophila metamorphosis.

References

  1. Truman, J.W. J. Neurobiol. 21, 1072–1084 (1990).

    Article  CAS  PubMed Central  Google Scholar 

  2. Lee, T., Marticke, S., Sung, C., Robinow, S. & Luo, L. Neuron 28, 807–818 (2000).

    Article  CAS  PubMed Central  Google Scholar 

  3. Boulanger, A. et al. Nat. Neurosci. 14, 37–44 (2011).

    Article  CAS  PubMed Central  Google Scholar 

  4. Zheng, X. et al. Cell 112, 303–315 (2003).

    Article  CAS  PubMed Central  Google Scholar 

  5. Lee, T., Lee, A. & Luo, L. Development 126, 4065–4076 (1999).

    CAS  Google Scholar 

  6. Awasaki, T. & Ito, K. Curr. Biol. 14, 668–677 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  7. Awasaki, T. et al. Neuron 50, 855–867 (2006).

    Article  CAS  PubMed Central  Google Scholar 

  8. Watts, R.J., Hoopfer, E.D. & Luo, L. Neuron 38, 871–885 (2003).

    Article  CAS  Google Scholar 

  9. Watts, R.J., Schuldiner, O., Perrino, J., Larsen, C. & Luo, L. Curr. Biol. 14, 678–684 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  10. Dorsett, D. Dev. Cell 14, 156–158 (2008).

    Article  CAS  PubMed Central  Google Scholar 

  11. Zheng, X. et al. EMBO J. 25, 615–627 (2006).

    Article  CAS  PubMed Central  Google Scholar 

  12. Lee, T. & Luo, L. Neuron 22, 451–461 (1999).

    Article  CAS  PubMed Central  Google Scholar 

  13. Malaspina, A., Pearce, R.K. & Graeber, M.B. Dev. Neurosci. 25, 375–383 (2003).

    Article  CAS  PubMed Central  Google Scholar 

  14. Tran, P.V. et al. Mol. Cell. Neurosci. 22, 441–453 (2003).

    Article  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA

    Takeshi Awasaki & Tzumin Lee

Authors
  1. Takeshi Awasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tzumin Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takeshi Awasaki.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Awasaki, T., Lee, T. Orphan nuclear receptors control neuronal remodeling during fly metamorphosis. Nat Neurosci 14, 6–7 (2011). https://doi.org/10.1038/nn0111-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0111-6

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing