A new study finds that retinoid X receptor-γ promotes remyelination. Its function in oligodendrocyte progenitor cell maturation sheds light on nuclear receptor signaling in myelin development and paves the way toward therapeutic ligands for myelin repair.
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References
Huang, J.K. et al. Nat. Neurosci. 14, 45–53 (2011).
Lazzarini, A. Myelin Biology and its Disorders (Elsevier Academic, San Diego, 2004).
Back, S.A. Ment. Retard. Dev. Disabil. Res. Rev. 12, 129–140 (2006).
Levine, J.M., Reynolds, R. & Fawcett, J.W. Trends Neurosci. 24, 39–47 (2001).
Windrem, M.S. et al. Nat. Med. 10, 93–97 (2004).
Franklin, R.J.M. & Ffrench-Constant, C. Nat. Rev. Neurosci. 9, 839–855 (2008).
Miller, R.H. Prog. Neurobiol. 67, 451–467 (2002).
Fancy, S.P.J. et al. Genes Dev. 23, 1571–1585 (2009).
Aguirre, A., Dupree, J.L., Mangin, J.M. & Gallo, V. Nat. Neurosci. 10, 990–1002 (2007).
Chang, A., Nishiyama, A., Peterson, J., Prineas, J. & Trapp, B.D. J. Neurosci. 20, 6404–6412 (2000).
Mey, J. J. Neurobiol. 66, 757–779 (2006).
Castillo, A.I. et al. Mol. Cell. Biol. 24, 502–513 (2004).
Széles, L. et al. Mol. Endocrinol. 24, 2218–2231 (2010).
de Urquiza, A.M. et al. Science 290, 2140–2144 (2000).
Barres, B.A., Lazar, M.A. & Raff, M.C. Development 120, 1097–1108 (1994).
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Gallo, V., Chew, LJ. An RXR-γ Rx for white-matter damage. Nat Neurosci 14, 3–5 (2011). https://doi.org/10.1038/nn0111-3
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DOI: https://doi.org/10.1038/nn0111-3
