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Upstream current for a downstream flow

Nature Neuroscience volume 20, pages 631633 (2017) | Download Citation

Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K+ via KIR2.1 inwardly rectifying K+ channels. The ensuing hyperpolarization travels upstream along the vascular network, reaching arterioles and evoking vasodilation.

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References

  1. 1.

    et al. Neuron 91, 851–862 (2016).

  2. 2.

    et al. Nature 508, 55–60 (2014).

  3. 3.

    & J. Neurosci. 34, 11504–11513 (2014).

  4. 4.

    et al. Nat. Neurosci. 19, 1619–1627 (2016).

  5. 5.

    Trends Neurosci. 28, 202–208 (2005).

  6. 6.

    et al. Nat. Neurosci. 20, 717–726 (2017).

  7. 7.

    , , & J. Cereb. Blood Flow Metab. 31, 1175–1186 (2011).

  8. 8.

    & Physiol. Rev. 95, 953–993 (2015).

  9. 9.

    & Neuroscience 129, 1043–1054 (2004).

  10. 10.

    & J. Neurochem. 107, 589–601 (2008).

  11. 11.

    et al. Nature 468, 232–243 (2010).

  12. 12.

    & Acta Physiol. (Oxf.) 203, 47–59 (2011).

  13. 13.

    , , , & J. Neurosci. 23, 9254–9262 (2003).

  14. 14.

    et al. Proc. Natl. Acad. Sci. USA 107, 3811–3816 (2010).

  15. 15.

    et al. Nat. Neurosci. 9, 1397–1403 (2006).

Download references

Author information

Affiliations

  1. Jessica A. Filosa is in the Department of Physiology, Augusta University, Augusta, Georgia, USA.

    • Jessica A Filosa

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Jessica A Filosa.

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DOI

https://doi.org/10.1038/nn.4542

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