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Glucose utilization: still in the synapse

Nature Neuroscience volume 20, pages 382384 (2017) | Download Citation

Many people still associate brain glucose metabolism with neurons. A new report shows that stimulation of astrocytic glutamate uptake increases glucose utilization, suggesting that astrocytes play a major role in the glucose uptake signal. However, this still reflects synaptic activity.

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References

  1. 1.

    et al. Acta Neurol. Scand. (suppl.) 64, 190–191 (1977).

  2. 2.

    , , , & Acta Neurol. Scand. (suppl.) 64, 192–193 (1977).

  3. 3.

    et al. Nat. Neurosci. 20, 393–395 (2017).

  4. 4.

    et al. Neuron 37, 275–286 (2003).

  5. 5.

    & Neuron 86, 883–901 (2015).

  6. 6.

    & Proc. Natl. Acad. Sci. USA 91, 10625–10629 (1994).

  7. 7.

    et al. Sci. Rep. 5, 16404 (2015).

  8. 8.

    et al. Nat. Commun. 7, 13441 (2016).

  9. 9.

    et al. J. Nucl. Med. 57, 954–960 (2016).

  10. 10.

    et al. Neuroimage 128, 54–62 (2016).

  11. 11.

    , , & Brain 138, 3685–3698 (2015).

  12. 12.

    & Ann. Neurol. 72, 635–647 (2012).

  13. 13.

    et al. J. Neurosci. 28, 4201–4209 (2008).

  14. 14.

    et al. Nature 494, 90–94 (2013).

  15. 15.

    et al. Nat. Commun. 6, 6807 (2015).

Download references

Author information

Affiliations

  1. A. Jon Stoessl is at the Pacific Parkinson's Research Centre, Division of Neurology & Djavad Mowafaghian Centre for Brain Health, University of British Columbia & Vancouver Coastal Health, Vancouver, Canada.

    • A Jon Stoessl

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The author declares no competing financial interests.

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Correspondence to A Jon Stoessl.

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DOI

https://doi.org/10.1038/nn.4513

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