Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.
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The authors thank S. Kerath, B. Sherry and S. Chavan for critically reading the manuscript. This work was supported by the following grants from the National Institute of General Medical Sciences, National Institutes of Health: R01GM089807 (to V.A.P. and K.J.T.) and R01GM057226 (to K.J.T.).
The authors declare that they are inventors named on patents related to the content of this manuscript. K.J.T. also declares that he is a consultant to SetPoint Medical.
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Pavlov, V., Tracey, K. Neural regulation of immunity: molecular mechanisms and clinical translation. Nat Neurosci 20, 156–166 (2017). https://doi.org/10.1038/nn.4477
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